Adverse Effects of Long Term Usage of Drugs or Topical Steroids

Reducing inflammation using drugs acts to help alleviate symptoms but does not necessarily promote healing or establish long term prevention. NSAIDS and Aspirin are commonly used to relieve both acute joint pain (often caused or aggravated by overuse, trauma and injury), as well as chronic debilitating conditions such as degenerative arthritis. While these two classes of drugs both alleviate pain, they also prevent the repair of the joint by blocking the formation and deposition of chondroitin sulphate.


Chondroitin sulfate is a major component of Extracellular Matrix (ECM), and is important in maintaining the structural integrity of the tissue. Loss of chondroitin sulfate from the cartilage is a major cause of osteoarthritis.


Prolonged use of the above medications can lead to cerebral, vascular, cardio, gastrointestinal and renal complications.


While topical steroids have tremendous benefit in reducing inflammation, they also have significant side effects. Most of these side effects are seen with long-term use, but some may be noticed within days of starting therapy.


MATRIXCELLTM Versus Steroids and Drugs for Inflammation

It is evident from Figure 3 that the application of MATRIXCELLTM resulted in a reduction of edema that was 82.6% as effective as the potent topical pharmaceutical betamethasone and 54% more effective than oral celecoxib (non-steroidal anti-inflammatory drug).